10 Postdoctoral Fellowship at Karolinska Institute, Sweden

The available postdoctoral position concerns developing and applying novel genomic approaches to study eukaryotic gene expression at an unprecedented scale combining experimental and computational approaches. The candidate will work in the context of a recently awarded ERC synergy project (EPIC – Unraveling the eukaryotic post-transcriptional regulatory code) in collaboration with the labs of Prof. Kevin Verstrepen (Leuven) and Prof. Julien Gagneur (Munich). EPIC will combine the use of genomic, synthetic biology, machine learning and evolutionary approaches with the aim to understand the complete gene expression regulatory code of S. cerevisiae and other eukaryotes. The recruited candidate will focus on mapping and prediction mRNA boundaries at an unprecedented scale. The candidate will also use the generated information to quantify and predict how mRNA variations lead to divergent mRNA fates.

The candidate will integrate different experimental and computational approaches for the completion of the project, including genomics, yeast genetics, high-throughput biology approaches and bioinformatics. The candidate will perform original research in transcriptomics and computational biology, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate will participate in the general duties of the team and effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

The project aims to understand the role of sensorimotor circuits for whole-body motor behavior in mice. The successful candidate should show a high level of responsibility and independency, be able to collaborate with others in a team, and possess good English communication skills. Applicants should have a strong neuroscience background with documented experience in using mice as a model system. We are seeking candidates with documented experience in surgery, animal behavior, virus injections, and electrophysiology. The project will involve patch-clamp recordings (including mechanoclamp recordings), optogenetics, and imaging in the mouse brainstem and spinal cord.

The project aims to understand the role of sensorimotor circuits for whole-body motor behavior in mice. The successful candidate should show a high level of responsibility and independency, be able to collaborate with others in a team, and possess good English communication skills. Applicants should have a strong neuroscience background with documented experience in using mice as a model system. We are seeking candidates with documented experience in surgery, animal behavior, virus injections, and electrophysiology. The project will involve patch-clamp recordings (including mechanoclamp recordings), optogenetics, imaging in the mouse brainstem and spinal cord.

Sex hormones do not only regulate reproduction, they also participate in healthy brain aging and in well-being. Still, it is not well-known how sex hormones regulate molecular processes that shape our brain and how they interact with risk and resilience factors that may account for sex differences in healthy brain aging. You will be part of a larger project that studies critical phases in life in which an individual’s susceptibility to depression and mental illness is heightened and strongly influenced by changes in endocrine signalling, namely pre- and early postnatal life, puberty, peripartum, and transition into older age. You will also be part of a project that studies the effect of young adult hormonal interventions in risk of developing Alzheimer’s disease. This project addresses the concerns about healthy-brain aging in transgender individuals that have undergone gender-affirming hormonal treatments. Animal behavior studies, epigenomic and single-cell transcriptomic analyses, and brain organoid development and culturing, are among the methods you will use in the lab. We work multidisciplinary by integrating experimental data with human epidemiological data. You are expected to be part of the group and to work and develop in accordance with the common group goals and research interests.

The successful candidate will apply and develop protocols including in vitro and ex vivo culture (2D and organoid), size exclusion chromatography, nanoparticle tracking analysis, flow cytometry, super-resolution microscopy, ex vivo organ culture, spatially resolved transcriptomics, histological and histochemical staining, immunofluoresence, electron microscopy and other relevant technologies, as applicable. The successful candidate will be given the opportunity to work towards scientific independence.

The project aims to combine animal models together with a unique cohort of early psoriatic arthritis to investigate new possibilities for therapy and diagnostics based on a deeper understanding of the underlying causes of the disease psoriatic vulgaris (PsV) and psoriatic arthritis (PsA). Mouse models are imperative to the success of the project, therefore mannan-induced psoriasis model will be used since it mimics the human disease better both genetically and functionally. Clinical samples from a large psoriasis cohort will be assessed to develop better serologic diagnosis for PsV and PsA. The project will also bridge animal research to Biotech companies in order to test experimental molecules and assess their effect on animal models of PsV and PsA. Lastly, single cell RNA sequencing and state-of-the-art proteomic analyses will be applied to uncover signalling pathways in targeted immune cell populations that are known to regulate psoriasis disease activity.

We are recruiting a postdoctoral fellow to work independently on a project in our creative environment. Your project will aim to understand how human white adipocytes are formed. More specifically, we have recently shown that human white adipose tissue contains three distinct adipocyte subtypes. In this project, we aim to understand from which progenitor cells they are formed. To achieve this, we will employ several state-of-the-art approaches including lineage tracing in transplantation models and advanced cell biology work based on human cells.

We are looking for a motivated postdoc for this 3-year project which has received funding from the Swedish Heart and Lung Foundation for the development of a model (Co-fam) that combines two evidence-based family support programmes, the universal “A Healthy School Start” with the targeted “More and Less”. Today, there is no cohesive family support for children with unhealthy lifestyles and a high BMI, which means that many children and their families do not receive the support they are entitled to according to national guidelines.

The team consists of researchers from five different departments at KI, but the project is located at the Department of Global Public Health in the research group Community Nutrition and Physical Activity (see link below). Together with parents, school and primary health care professionals we will co-design the model linking these two programs in an effective way. In a municipality with great health needs, we have implemented the 1-year program “A Healthy School Start” in grade 1 since 2022. In order for children with greater needs to receive increased evidence-based support after grade 1, we will co-design a model so that these children and their parents have the opportunity to participate in the “More and Less” program given by dieticians and other staff in primary healthcare. The model will then be evaluated in a controlled study for 14-18 months.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a postdoc to join the Medical Inflammation Research group. We suggest a project to analyze the NCF1 mediated regulation and antigen-selection of   B suppressor cells (see Aoun et al JEM 2023). This will involve identification of the B cell VDJ repertoire for B suppressor cells at different tissue locations.

We are looking for one talented and highly motivated postdoctoral researchers with an interest to work with multi-tracer in vivo PET study, measuring  different pathological markers including beta amyloid and tau deposition, astrogliosis, synapse function and impairment, combined with cognitive tests, cerebrospinal fluid (CSF) and plasma biomarkers and MRI. We expect the applicant to take an active role in applying advanced imaging methods for processing and evaluating PET, MRI imaging data, performing statistical analyses, and preparing scientific manuscripts under supervision. The group provides excellent training opportunities in an international working environment, national and international collaborations, and possibilities to publish articles in high-impact journals.